ACHIEVEMENT

Original Paper | Review

Original Paper

  1. S. E. Muttaqien, T. Nomoto*, H. Takemoto, M. Matsui, K. Tomoda, N. Nishiyama*, Poly(N-isopropylacrylamide)-Based Polymer-Inducing Isothermal Hydrophilic-to-Hydrophobic Phase Transition via Detachment of Hydrophilic Acid-Labile Moiety. Biomacromolecules 20 (4) 1493-1504 (2019) (DOI: 10.1021/acs.biomac.8b01465)
  2. R. Toshiyama R, M. Konno, H. Eguchi, H. Takemoto, T. Noda, A. Asai, J. Koseki, N. Haraguchi, Y. Ueda, K. Matsushita, K. Asukai, T. Ohashi, Y. Iwagami, D. Yamada, D. Sakai, T. Asaoka, T. Kudo, K. Kawamoto, K. Gotoh, S. Kobayashi, T. Satoh, Y. Doki, N. Nishiyama, M. Mori, H. Ishii*, Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells. Oncogene, in press.
  3. X. Dou, T. Nomoto*, H. Takemoto, M. Matsui, K. Tomoda, N. Nishiyama*, Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers. Sci. Rep. 8 (1) 6077 (2018) (doi:10.1038/s41598-018-26593-0) [PDF]
  4. A.-H. Ranneh, H. Takemoto*, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama*, An ethylenediamine-based switch to control the polyzwitterion charge at tumorous pH for effective tumor accumulation of coated nanomaterials. Angew. Chem. Int. Ed. 57(18) 5057-5061 (2018) (DOI: 10.1002/anie.201801641)
  5. Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota*, K. Kataoka*, Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nature Commun. 8 1001 (2017) (DOI: 10.1038/s41467-017-00952-3)
  6. M. Maeda, Y. Muragaki*, J. Okamoto, S. Yoshizawa, N. Abe, H. Nakamoto, H. Ishii, K. Kawabata, S. Umemura, N. Nishiyama, K. Kataoka, H. Iseki, Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound. Ultrasound Med. Biol. 43 (10) 2295-2301 (2017) (DOI: 10.1016/j.ultrasmedbio.2017.06.003)
  7. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka*, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 261 275-286 (2017) (DOI: 10.1016/j.jconrel.2017.06.021)
  8. S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka*, cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J. Control. Release 258 56-66 (2017) (DOI: 10.1016/j.jconrel.2017.04.033)
  9. H. Taniguchi*, D. Hoshino, C. Moriya, H. Zembutsu, N. Nishiyama, H. Yamamoto, K. Kataoka, K. Imai, Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer. Oncotarget 8 29 46856-46874 (2017) (DOI: 10.18632/oncotarget.16776)
  10. N. Yamada, Y. Honda, H. Takemoto, T. Nomoto, Makoto M., K. Tomoda, M. Konno, H. Ishii, M. Mori, N. Nishiyama*, Engineering tumour cell-binding synthetic polymers with sensing dense transporters associated with aberrant glutamine metabolism. Sci. Rep. 7 (1) 6077 (2017) (doi: 10.1038/s41598-017-06438-y.) [PDF]
  11. P. Mi*, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral*, K. Kataoka*, N. Nishiyama*, Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors. J. Control. Release 254 1-9 (2017) (DOI: 10.1016/j.jconrel.2017.03.036)
  12. M. Naito, R, Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H.J. Kim, T. Ishii, N. Nishiyama, K. Miyata*, K. Kataoka*, Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery. J. Biomater. Sci. Polym. Ed. 28 (10-12) 1109-1123 (2017) (DOI: 10.1080/09205063.2017.1301775)
  13. C. Moriya, H. Taniguchi*, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai, Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. Carcinogenesis 38 (6) 638-648 (2017) (DOI: 10.1093/carcin/bgx040)
  14. C. H. Huang, H. Takemoto*, T. Nomoto, K. Tomoda, M. Matsui, N. Nishiyama*, Utility of the 2-nitrobenzenesulfonamide group as a chemical linker for enhanced extracellular stability and cytosolic cleavage in siRNA-conjugated polymer systems. ChemMedChem 12 (1) 19-22 (2017)  (DOI: 10.1002/cmdc.201600488) [selected as a front cover image]
  15. N. F. Che Harun, H. Takemoto*, T. Nomoto, K. Tomoda, M. Matsui, N. Nishiyama*, Artificial control of gene silencing activity based on siRNA conjugation with polymeric molecule having coil–globule transition behavior. Bioconjugate Chem. 27 (9) 1961-1964 (2016) (DOI: 10.1021/acs.bioconjchem.6b00322)
  16. H. Hino, M. Kamiya, K. Kitano, K. Mizuno, S. Tanaka, N. Nishiyama, K. Kataoka, Y. Urano*, J. Nakajima*, Rapid cancer fluorescence imaging using a γ-glutamyltranspeptidase-specific probe for primary lung cancer. Transl Oncol. 9 (3) 203-210 (2017) (DOI: 10.1016/j.tranon.2016.03.007)
  17. M. Iijima, D. Ulkoski, S. Sakuma, D. Matsukuma, N. Nishiyama, H. Otsuka, C. Scholz*, Synthesis of PEGylated poly(amino acid) pentablock copolymers and their self-assembly. Polymer International 65 (10) 1132-1141 (2016) (DOI: 10.1002/pi.5159)
  18. P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki*, N. Nishiyama*, K. Kataoka*, A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy. Nat. Nanotechnol. 11 (8) 724-730 (2016) (DOI: 10.1038/nnano.2016.72)
  19. H. Kinoh, Y. Miura, T. Chida, X. Liu, K. Mizuno, S. Fukushima, Y. Morodomi, N. Nishiyama, H. Cabral*, K. Kataoka*, Nanomedicines eradicating cancer stem-like cells in vivo by pH-triggered intracellular cooperative action of loaded drugs. ACS Nano 10 (6) 5643-5655 (2016) (DOI: 10.1021/acsnano.6b00900)
  20. Y. Matsumoto, Y. Miyamoto, H. Cabral, Y. Matsumoto, K. Nagasaka, S. Nakagawa*, D. Maeda, T. Yano, K. Oda, K. Kawana, N. Nishiyama, K. Kataoka*, T. Fujii, Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132. Cancer Sci. 107 (6) 773-781 (2016) (DOI: 10.1111/cas.12926)
  21. Y. Matsumoto, J. W. Nichols, K. Toh, T. Nomoto, H. Cabral, Y. Miura, R. J. Christie, N. Yamada, T. Ogura, M. R. Kano, Y. Matsumura, N. Nishiyama, T. Yamasoba, Y. -H. Bae*, K. Kataoka*, Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nature Nanotech. 11 (6) 533-538 (2016) (DOI: 10.1038/nnano.2015.342) [Highlighted in Nature Nanotech, 11 (6) 494-496 (2016)]
  22. H. Nishida, Y. Matsumoto, K. Kawana*, R. J. Christie, M. Naito, B. -S. Kim, K. Toh, H. -S. Min, Y. Yi, Y. Matsumoto, H. -J. Kim, K. Miyata, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka*, Y. Osuga, T. Fujii, Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J. Control. Release 231 29-37 (2016) (DOI: 10.1016/j.jconrel.2016.03.016)
  23. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral*, K. Kataoka*, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 230 26-33 (2016) (DOI: 10.1016/j.jconrel.2016.03.038)
  24. T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama*, K. Kataoka*, Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy. Biomater. Sci. 4 (5) 826-838 (2016) (DOI: 10.1039/C6BM00011H) [selected as an inside front cover image]
  25. K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata*, K. Kataoka*, Influence of RNA strand rigidity on polyion complex formation with block catiomers. Macromol. Rapid Commun. 37 (6) 486-493 (2016) (DOI: 10.1002/marc.201500661)
  26. N. Dewi, P. Mi, H. Yanagie*, Y. Sakurai, Y. Morishita, M. Yanagawa, T. Nakagawa, A. Shinohara, T. Matsukawa, K. Yokoyama, H. Cabral, M. Suzuki, Y. Sakurai, H. Tanaka, K. Ono, N. Nishiyama, K. Kataoka, H. Takahashi, In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent. J. Cancer Res. Clin. Oncol. 142 (4) 767-775 (2016) (DOI: 10.1007/s00432-015-2085-0)
  27. H. Uchida, K. Itaka, S. Uchida, T. Ishii, T. Suma, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka*, Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure. J. Am. Chem. Soc. 138 (5) 1478-1481 (2016) (DOI: 10.1021/jacs.5b11726)
  28. A. Kim, Y. Miura, T. Ishii, O. F. Mutaf, N. Nishiyama, H. Cabral, K. Kataoka*, Intracellular delivery of charge-converted monoclonal antibodies by combinatorial design of block/homo polyion complex micelles. Biomacromolecules 17 (2) 446-453 (2016) (DOI: 10.1021/acs.biomac.5b01335)
  29. Y. Anraku, A. Kishimura*, M. Kamiya, S. Tanaka, T. Nomoto, K. Toh, Y. Matsumoto, S. Fukushima, D. Sueyoshi, M. R. Kano, Y. Urano, N. Nishiyama, K. Kataoka*, Systemically injectable enzyme-loaded polyion complex vesicles as in vivo nanoreactors functioning in tumors. Angew. Chem. Int. Ed. 128 (2) 570-575 (2016) (DOI: 10.1002/ange.201508339)
  30. M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. -J. Kim, Y. Miura, J. -Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata*, K. Kataoka*, siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy. Biomacromolecules 17 (1) 246-255 (2016) (DOI: 10.1021/acs.biomac.5b01334)
  31. J. Makino, H. Cabral*, Y. Miura, Y. Matsumoto, M. Wang, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka*, CRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 220 PartB 783-791 (2015) (DOI:10.1016/j.jconrel.2015.10.017)
  32. M. Murakami*, K. Nishina, C. Watanabe, K. Y. Tanaka, W. Piao, H. Kuwahara, Y. Horikiri, K. Miyata, N. Nishiyama, K. Kataoka, M. Yoshida, H. Mizusawa, T. Yokota*, Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Sci. Rep. 5 17035 (2015) (DOI: 10.1038/srep17035)
  33. Y. Miura, A. B. Tsuji, A. Sugyo, H. Sudo, I. Aoki, M. Inubushi, M. Yashiro, K. Hirakawa, H. Cabral, N. Nishiyama, T. Saga*, K. Kataoka*, Polymeric micelle platform for multimodal tomographic imaging to detect scirrhous gastric cancer. ACS Biomater. Sci. Eng. 1 (11) 1067-1076 (2015) (DOI: 10.1021/acsbiomaterials.5b00142)
  34. K. S. –Kato*, K. Nanjo, H. Kusuhara, N. Nishiyama, K. Kataoka, T. Kawanishi, H. Okuda, Y. Goda, Effect of knockout of Mdr1a and Mdr1b ABCB1 genes on the systemic exposure of a doxorubicin-conjugated block copolymer in mice. Mol. Pharm. 12 19 3175-3183 (2015) (DOI: 10.1021/acs.molpharmaceut.5b00234)
  35. P. Mi, N. Dewi, H. Yanagie, D. Kokuryo, M. Suzuki, Y. Sakurai, Y. Li, I. Aoki, K. Ono, H. Takahashi, H. Cabral, N. Nishiyama*, K. Kataoka*, Hybrid calcium phosphate-polymeric micelles incorporating gadolinium chelates for imaging-guided gadolinium neutron capture tumor therapy. ACS Nano 9 (6) 5913-5921 (2015) (DOI: 10.1021/acsnano.5b00532)
  36. W. Kawamura, Y. Miura, D. Kokuryo, K. Toh, N. Yamada, T. Nomoto, Y. Matsumoto, D. Sueyoshi, X. Liu, I. Aoki, M. R. Kano, N. Nishiyama, T. Saga, A. Kishimura, K. Kataoka*, Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas. Sci. Technol. Adv. Mater. 16 (3) 035004 (2015) (DOI: 10.1088/1468-6996/16/3/035004)
  37. H. Cabral, J. Makino, Y. Matsumoto, P. Mi, H. Wu, T. Nomoto, K. Toh, N. Yamada, Y. Higuchi, S. Konishi, M. R. Kano, H. Nishihara, Y. Miura, N. Nishiyama, K. Kataoka*, Systemic targeting of lymph node metastasis through the blood vascular system by using size-controlled nanocarriers. ACS Nano 9 (5) 4957-4967 (2015) (DOI: 10.1021/nn5070259)
  38. H. Ogawa, X. Wu, K. Kawamoto, N. Nishida, M. Konno, J. Koseki, H. Matsui, K. Noguchi, N. Gotoh, T. Yamamoto, K. Miyata, N. Nishiyama, H. Nagano, H. Yamamoto, S. Obika, K. Kataoka, Y. Doki, M. Mori*, H. Ishii*, MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells. PLOS ONE 10(5) e0127119 (2015) (DOI: 10.1371/journal.pone.0127119)
  39. J. -Y. Ahn, Y. Miura, N. Yamada, T. Chida, X. Liu, A. Kim, R. Sato, R. Tsumura, Y. Koga, M. Yasunaga, N. Nishiyama, Y. Matsumura, H. Cabral, K. Kataoka*, Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer. Biomaterials 39 23-30 (2015) (DOI: 10.1016/j.biomaterials.2014.10.069)
  40. H.-C. Yen, H. Cabral, P. Mi, K. Toh, Y. Matsumoto, X. Liu, H. Koori, A. Kim, K. Miyazaki, Y. Miura, N. Nishiyama, K. Kataoka*, Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy. ACS Nano 8 (11) 11591-11602 (2014) (DOI: 10.1021/nn504836s)
  41. H. -J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata*, K. Kataoka*, Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano 8 (9) 8979-8991 (2014) (DOI: 10.1021/nn502125h)
  42. H. Wu, H. Cabral*, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka*, Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation. J. Control. Release 189, 1-10 (2014) (DOI: 10.1016/j.jconrel.2014.06.018)
  43. H. Uchida, K. Itaka, T. Nomoto, T. ishii, T. Suma, M. Ikegami, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka*, Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. J. Am. Chem. Soc. 136 (35) 12396-12405 (2014) (DOI: 10.1021/ja506194z) [Selected as Spotlights of JACS]
  44. Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata*, K. Kataoka*, Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials 35(27) 7887-7895 (2014)(DOI: 10.1016/j.biomaterials.2014.05.041)
  45. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka*, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to effcient antitumor therapy. J. Control. Release (188) 67-77 (2014) (DOI: 10.1016/j.jconrel.2014.05.048)
  46. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama*, K. Kataoka*, Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor. ACS Nano 8 (7) 6724-6738 (2014) (DOI: 10.1021/nn500498t)
  47. Y. Maeda, F. Pittella, T. Nomoto, H. Takemoto, N. Nishiyama, K. Miyata*, K. Kataoka*, Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles. Macromol. Rapid Commun. 35 (13) 1211-1215 (2014) (DOI: 10.1002/marc.201400049)
  48. H. -J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka*, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014) (DOI: 10.1016/j.biomaterials.2014.02.016)
  49. T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama*, K. Kataoka*, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nature Commun. 5 3545 (2014) (DOI: 10.1038/ncomms4545)
  50. H. -J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka*, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014) (DOI: 10.1016/j.biomaterials.2014.02.016)
  51. C. V. Synatschke, T. Nomoto, H. Cabral, M. Fortsch, K. Toh, Y. Matsumoto, K. Miyazaki, A. Hanisch, F. H. Schacher, A. Kishimura, N. Nishiyama, A. H. E. Mueller, K. Kataoka*, Multicompartment micelles with adjustable poly(ethylene glycol) shell for efficient in vivo photodynamic therapy. ACS Nano 8 (2) 1161-1172 (2014)  (DOI: 10.1021/nn4028294)
  52. F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. Takemoto, H. -J. Kim, N. Nishiyama, K. Miyata, K. Kataoka*, Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J. Control. Release 178 18-24 (2014) (DOI: 10.1016/j.jconrel.2014.01.008)
  53. H. -J. Kim, T. Ishii, M. Zheng, S. Watanabe, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata*, K. Kataoka*, Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Deliv. Transl. Res. 4 (1) 50-60 (2014) (DOI: 10.1007/s13346-013-0175-6)
  54. K. S. –Kato*, K. Un, K. Nanjo, N. Nishiyama, H. Kusuhara, K. Kataoka, T. Kawanishi, Y. Goda, H. Okuda, Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components. Biomaterials 35 (5) 1347-1358 (2014) (DOI: 10.1016/j.biomaterials.2013.11.027) [Selected as Leading Opinion Paper]
  55. P. Mi, D. Kokuryo, H. Cabral, M. Kumagai, T. Nomoto, I. Aoki, Y. Terada, A. Kishimura, N. Nishiyama*, K. Kataoka*, Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors. J. Control. Release 174 63-71 (2014) (DOI: 10.1016/j.jconrel.2013.10.038)
  56. H. Chen, L. Xiao, Y. Anraku, P. Mi, X. Liu, H. Cabral, A. Inoue, T. Nomoto, A. Kishimura*, N. Nishiyama*, K. Kataoka*, Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J. Am. Chem. Soc. 136 (1) 157-163 (2014) (DOI: 10.1021/ja406992w)
  57. Y. Miura, T. Takenaka, K. Toh, S. Wu, H. Nishihara, M. R. Kano, Y. Ino, T. Nomoto, Y. Matsumoto, H. Koyama, H. Cabral, N. Nishiyama*, K. Kataoka*, Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier. ACS Nano 7 (10) 8583-8592 (2013) (DOI: 10.1021/nn402662d)
  58. S. Deshayes, H. Cabral, T. Ishii, Y. Miura, S. Kobayashi, T. Yamashita, A. Matsumoto, Y. Miyahara, N. Nishiyama, K. Kataoka*, Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors. J. Am. Chem. Soc. 135 (41) 15501-15507 (2013) (DOI: 10.1021/ja406406h)
  59. H. Cabral, M. Murakami, H. Hojo, Y. Terada, M. R. Kano, U. -I. Chung, N. Nishiyama*, K. Kataoka*, Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc. Natl. Acad. Sci. USA. 110 (28) 11397-11402 (2013) (DOI: 10.1073/pnas.1301348110) [PDF]
  60. D. Kokuryo, Y. Anraku, A. Kishimura, S. Tanaka, M. R. Kano, J. Kershaw, N. Nishiyama, T. Saga, I. Aoki, K. Kataoka*, SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes). J. Control. Release 169 (3) 220-227 (2013) (DOI: 10.1016/j.jconrel.2013.03.016)
  61. H. Takemoto, K. Miyata, S. Hattori, T. Ishii, T. Suma, S. Uchida, N. Nishiyama, K. Kataoka*, Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. Angew. Chem. Int. Ed. 52 (24) 6218-6221 (2013) (DOI: 10.1002/anie.201300178)
  62. S. Wu*, V. Kasim, M. R Kano, S. Tanaka, S. Ohba, Y. Miura, K. Miyata, X. Liu, A. Matsuhashi, U.-l Chung, K. Kataoka, N. Nishiyama*, M. Miyagishi*, Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res. 73 (6) 1787-1799 (2013) (DOI: 10.1158/0008-5472.CAN-12-0366)
  63. P. Mi, H. Cabrala, D. Kokuryo, M. Rafi, Y. Terada, I. Aoki, T. Saga, T. Ishii, N. Nishiyama*, K. Kataoka*, Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging. Biomaterials 34 (2) 492-500 (2013) (DOI: 10.1016/j.biomaterials.2012.09.030)
  64. N. Gouda, K. Miyata*, R.J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka*, Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA. Biomaterials 34 (2) 562-570 (2013) (DOI: 10.1016/j.biomaterials.2012.09.077)
  65. M. Sanjoh, K. Miyata*, R. J. Christie, T. Ishii, Y. Maeda, F. Pittella, S. Hiki, N. Nishiyama, K. Kataoka*, A dual environment-responsive polyplex carrier for enhanced intracellular delivery of plasmid DNA. Biomacromolecules 13 (11) 3641-3649 (2012) (DOI: 10.1021/bm301095a)
  66. T. Suma, K. Miyata*, Y. Anraku, S. Watanabe, R. J. Christie, H. Takemoto, M. Shioyama, N. Gouda, T. Ishii, N. Nishiyama, K. Kataoka*, Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG. ACS Nano 6 (8) 6693-6705 (2012) (DOI: 10.1021/nn301164a)
  67. F. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka*, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. J. Control. Release 161 (3) 868-874 (2012) (DOI: 10.1016/j.jconrel.2012.05.005)
  68. K. Osada, H. Cabral, Y. Mochida, S. -E. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka*, Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation. J. Am. Chem. Soc. 134 (32) 13172-13175 (2012) (DOI: 10.1021/ja304615y)
  69. H. Takemoto, K. Miyata, T. Ishii, S. Hattori, S. Osawa, N. Nishiyama, K. Kataoka, Accelerated polymer-polymer click conjugation by freeze-thaw treatment. Bioconjugate. Chem. 23 (8) 1503-1506 (2012) (DOI: 10.1021/bc300182y) [Selected as Cover Picture]
  70. K. Miyazaki, Y. Morimoto*, N. Nishiyama, Y. Maekawa, W.-Z. Hu, K. Nakatate, K. Kaneda, N. Shinomiya, K. Kataoka, A novel homogeneous irradiation fiber probe for whole bladder wall photodynamic therapy. Lasers Surg. Med. 44 (5) 413– 420 (2012) (DOI: 10.1002/lsm.22010)
  71. M. Kumagai, S. Shimoda, R. Wakabayashi, Y. Kunisawa, T. Ishii, K. Osada, K. Itaka, N. Nishiyama, K. Kataoka, K. Nakano*, Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination. J. Control. Release 160 (3) 542-551 (2012) (DOI: 10.1016/j.jconrel.2012.03.021)
  72. R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. -J. Kim, N. Nishiyama, K. Kataoka*, Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 6 (6) 5174-5189 (2012) (DOI: 10.1021/nn300942b)
  73. Md. Rafi, H. Cabral, M.R. Kano, P. Mi, C. Iwata, M. Yashiro, K. Hirakawa, K. Miyazono, N. Nishiyama*, K. Kataoka*, Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis. J. Control. Release 159 (2) 189-196 (2012) (DOI: 10.1016/j.jconrel.2012.01.038)
  74. T. Suma, K. Miyata, T. Ishii, S. Uchida, H. Uchida, K. Itaka, N. Nishiyama, K. Kataoka*, Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials 33 (9) 2770-2779 (2012) (DOI: 10.1016/j.biomaterials.2011.12.022)
  75. K. Sakai-Kato*, K. Ishikura, Y. Oshima, M. Tada, T. Suzuki, A. Ishii-Watabe, T. Yamaguchi, N. Nishiyama, K. Kataoka, T. Kawanishi, H. Okuda, Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubicin-bound block copolymers. Int. J. Pharm. 423 (2) 401– 409 (2012) (DOI: 10.1016/j.ijpharm.2011.12.022)
  76. M. Baba, Y. Matsumoto, A. Kashio, H. Cabral, N. Nishiyama, K. Kataoka, T. Yamasoba*, Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs. J. Control. Release 157 (1) 112-117 (2012) (DOI: 10.1016/j.jconrel.2011.07.026)
  77. H.-J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka*, PEG-detachable cationic polyaspartamide detivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor. J. Drug Target. 20 (1) 33-42 (2011) (DOI: 10.3109/1061186X.2011.632010)
  78. F. M. Mickler, Y. Vachutinsky, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, C. Brachle, N. Ruthardt*, Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. J. Control. Release 156 (3) 364-373 (2011) (DOI:10.1016/j.jconrel.2011.08.003)
  79. A. Iriyama*, M. Oba, T. Ishii, N. Nishiyama, K. Kataoka, Y. Tamaki, Y. Yanagi, Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo. PLoS One 6(12) e28560 (2011) (DOI: 10.1371/journal.pone.0028560)
  80. A. Iriyama*, T. Usui, Y. Yanagi, S. Amano, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo. Cornea 30 (12) 1423-1427 (2011) (DOI: 10.1097/ICO.0b013e318206c893)
  81. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M.R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama*, K. Kataoka*, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nature Nanotech. 6 (12) 815-823 (2011) (DOI: 10.1038/nnano.2011.166)
  82. S. Herlambang, M. Kumagai, S. Horie, S. Fukushima, M. Oba, T. Nomoto, K. Miyazaki, Y. Morimoto, N. Nishiyama*, K. Kataoka*, Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy. J. Control. Release 155 (3) 449-457 (2011) (DOI:10.1016/j.jconrel.2011.06.019)
  83. H.-L. Lu, W.-J. Syu, N. Nishiyama, K. Kataoka, P.-S. Lai*, Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcome the drug-resistance in vivo. J. Control. Release 155 (3) 458-464 (2011) (DOI: 10.1016/j.jconrel.2011.06.005)
  84. H. Uchida, K. Miyata, M. Oba, T. Ishii, T. Suma, K. Itaka, N. Nishiyama, K. Kataoka*, Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. J. Am. Chem. Soc. 133 (39) 15524-15532 (2011) (DOI: 10.1021/ja204466y)
  85. R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T. -C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka*, Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines. Biomacromolecules 12 (9) 3174-3185 (2011) (DOI: 10.1021/bm2006714)
  86. T. Nomoto, Y. Matsumoto, K. Miyata, M. Oba, S. Fukushima, N. Nishiyama, T. Yamasoba, K. Kataoka*, In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J. Control. Release 151 (2) 104-109 (2011) (DOI: 10.1016/j.jconrel.2011.02.011) [Selected as Cover Picture]
  87. F. Pittella, M. Zhang, Y. Lee, H. -J. Kim, T. Tockary, K. Osada, T. Ishii, K. Miyata, N. Nishiyama, K. Kataoka*, Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 32 (11) 3106-3114 (2011) (DOI: 10.1016/j.biomaterials.2010.12.057)
  88. M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka*, Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 32 (2) 652-663 (2011) (DOI: 10.1016/j.biomaterials.2010.09.022)
  89. M. Murakami, H. Cabral, Y. Matsumoto, S. Wu, M. R. Kano, T. Yamori, N. Nishiyama*, K. Kataoka*, Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Science Transl. Med. 3 (64) 64ra2 (2011) (DOI: 10.1126/scitranslmed.3001385) [Selected as Cover Picture]
  90. Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka*, Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release 149 (1) 51-57 (2011) (DOI: 10.1016/j.jconrel.2010.02.002)
  91. H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka*, siRNA-grafted polymer for polyion complex (PIC)-based siRNA delivery: Enhancement of PIC stability and gene silencing efficiency. Biomaterials 31 (31) 8097-8105 (2010) (DOI:10.1016/j.biomaterials. 2010.07.015)
  92. Y. Matsumoto, T. Nomoto, H. Cabral, Y. Matsumoto, S. Watanabe, R. J. Christie, K. Miyata, M. Oba, T. Ogura, Y. Yamasaki, N. Nishiyama, T. Yamasoba, K. Kataoka*, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Express 1 (4) 1209-1216 (2010) (DOI: 10.1364/BOE. 1.001209)
  93. S. Kaida, H. Cabral, M. Kumagai, A. Kishimura, Y. Terada, M. Sekino, I. Aoki, N. Nishiyama, T. Tani, K. Kataoka*, Visible-drug delivery by supra-molecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. Cancer Res. 70 (18) 7031-7041 (2010) (DOI: 10.1021/ ja102739b) [Selected as Cover Sidebar]
  94. M. Kumagai, T. K. Sarma, H. Cabral, S. Kaida, M. Sekino, N. Herlambang, K. Osada, M. R. Kano, N. Nishiyama, K. Kataoka*, Enhanced In vivo magnetic resonance imaging of tumors by PEGylated iron oxide-gold core-shell nanoparticles with prolonged blood circulation properties. Macromol. Rapid Commun. 31 (17) 1521-1528 (2010) (DOI: 10.1002/marc.201000341) [Selected as Cover Picture]
  95. H. -J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka*, Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145 (2) 141-148 (2010) (DOI:10.1016/j.jconrel.2010.03.019)
  96. K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka*, Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials, 31 (17) 4764-4770 (2010) (DOI: 10.1016/j.biomaterials.2010.02.033)
  97. M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka*, Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharm. 7 (2) 501-509 (2010) (DOI: 10.1021/mp9002317)
  98. H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita*, siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21 (4) 622-633 (2010) (DOI: 10.1681/ASN.2009030295)
  99. Y. Lee, T. Ishii, H. -J. Kim, N. Nishiyama, Y. Hayakawa, K. Itaka, K. Kataoka*, Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles. Angew. Chem. Int. Ed. 49 (14) 2552-2555 (2010) (DOI: 10.1002/ anie.200905264)
  100. M. Kumagai, M. R. Kano, Y. Morishita, M. Ota, Y. Imai, N. Nishiyama, M. Sekino, S. Ueno, K. Miyazono, K. Kataoka*, Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block-copolymer-coated magnetite nanoparticles combined with TGF-beta inhibitor. J. Control. Release 140 (3) 306-311 (2009) (DOI: 10.1016/j.jconrel.2009.06.002)
  101. M. Zhang, A. Ishii, N. Nishiyama, S. Matsumoto, T. Ishii, Y. Yamasaki, K. Kataoka*, PEGylated calcium phosphate nanocomposites as smart environment-sensitive carriers for siRNA delivery. Adv. Mater. 21 (34) 3520-3525 (2009) (DOI: 10.1002/adma.200800448)
  102. M. Han, M. Oba, N. Nishiyama, M.R. Kano, S. Kizaka-Kondoh, K. Kataoka*, Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles. Mol. Ther.17 (8) 1404-1410 (2009) (DOI: 10.1038/mt.2009.119)
  103. M. Harada-Shiba, I. Takamisawa, K. Miyata, T. Ishii, N. Nishiyama, K. Itaka, K. Kangawa, F. Yoshihara, Y. Asada, K. Hatakeyama, N. Nagaya, K. Kataoka*, Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Mol. Ther. 17 (7) 1180-1186 (2009) (DOI: 10.1038/mt.2009.63)
  104. Y. Lee, T. Ishii, H. Cabral, H. -J. Kim, J. -H. Seo, N. Nishiyama, H. Oshima, K. Osada, K. Kataoka*, Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. Angew. Chem. Int. Ed. 48 (29) 5309-5312 (2009)  (DOI: 10.1002/anie.200900721) [Selected as Inner Cover Picture]
  105. W. Wang, K. Itaka, S. Ohba, N. Nishiyama, U. Chung, Y. Yamasaki, K. Kataoka*, Improving multipotent differentiation efficiency of mesenchymal stem cells using 3D spheroids method on micropatterned substrates. Biomaterials 30 (14) 2705-2715 (2009) (DOI: 10.1016/j.biomaterials.2009.01.030)
  106. N. Nishiyama, Y. Nakagishi, Y. Morimoto, P.-S. Lai, K. Miyazaki, K. Urano, S. Horie, M. Kumagai, S. Fukushima, Y. Cheng, W.-D. Jang, M. Kikuchi, K. Kataoka*, Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. J. Control. Release 133 (3) 245-251 (2009) (DOI: 10.1016/j.jconrel.2008.10.010) [Selected as Cover Picture]
  107. S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka*, Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10 (1) 119-127 (2009) (DOI: 10.1021/bm800985e)
  108. H. Cabral, M. Nakanishi, M. Kumagai, W.-D. Jang, N. Nishiyama, K. Kataoka*, A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles. Pharm. Res. 26 (1) 82-92 (2009) (DOI: 10.1007/s11095-008-9712-2)
  109. K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka*, Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J. Am. Chem. Soc. 130 (48) 16287-16294 (2008) (DOI: 10.1021/ja804561g)
  110. K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka*, Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue. Pharm. Res. 25 (12) 2924-2936 (2008) (DOI: 10.1007/s11095-008-9720-2)
  111. M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka*, Polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinks directing to the enhanced transfection via controlled intracellular trafficking. Mol. Pharm. 5 (6) 1080-1092 (2008) (DOI: 10.1021/mp800070s) [Selected as Cover Picture]
  112. S. Wu, N. Nishiyama, M. R. Kano, Y. Morishita, K. Miyazono, K. Itaka, U. Chung, K. Kataoka*, Enhancement of angiogenesis through stabilization of hypoxia inducible factor-1 by silencing prolyl hydroxylase domain 2 gene. Mol. Ther. 16 (7) 1227-1234 (2008) (DOI: 10.1038/mt.2008.90)
  113. Y. Lee, K. Miyata, M. Oba, T. Ishii, S. Fukushima, M. Han, N. Nishiyama, K. Kataoka*, Charge-conversional ternary polyplex with endosome disruption moiety: a new paradaigm for the efficient and safe gene delivery. Angew. Chem., Int. Ed. 47 (28) 5163-5166 (2008) (DOI: 10.1002/anie.200800963)
  114. S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka*, PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive non-viral gene vectors. J. Am. Chem. Soc. 130 (18) 6001-6009 (2008) (DOI: 10.1021/ja800336v)
  115. K. Sugisaki, T. Usui*, N. Nishiyama, W.-D. Jang, Y. Yanagi, S. Yamagami, S. Amano, K. Kataoka, Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins. Invest, Ophth. Vis. Sci. 49 (3) 894-899 (2008) (DOI: 10.1167/iovs.07-0389)
  116. K. Masago, K. Itaka, N. Nishiyama, U. Chung, K. Kataoka*, Gene delivery with biocompatible cationic polymer: pharmacogenomic analysis on cell bioactivity. Biomaterials 28 (34) 5169-5175 (2007) (DOI: 10.1016/j.biomaterials.2007.07.019)
  117. Y. Li, W.-D. Jang, N. Nishiyama, A. Kishimura, S. Kawauchi, Y. Morimoto, S. Miake, T. Yamashita, M. Kikuchi, T. Aida, K. Kataoka*, Dendrimer generation effects on photodynamic efficacy of dendrimer porphyrins and dendrimer-loaded supramolecular nanocarriers. Chem. Mater. 9 (23) 5557-5562 (2007) (DOI: 10.1021/cm071451m)
  118. K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka*, PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J. Control. Release 122 (3) 252-260 (2007) (DOI: 10.1016/j.jconrel.2007.06.020)
  119. M. Oishi, Y. Nagasaki, N. Nishiyama, K. Itaka, M. Takagi, A. Shimamoto, Y. Furuichi, K. Kataoka*, Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. ChemMedChem 2 (9) 1290-1297 (2007) (DOI: 10.1002/cmdc.200700076)
  120. M. P. Xiong, Y. Bae, S. Fukushima, M. L. Forrest, N. Nishiyama, K. Kataoka, G. S. Kwon*, pH-Responsive multi-PEGylated dual cationic nanoparticles enable charge modulations for safe gene delivery. ChemMedChem 2 (9) 1321-1327 (2007) (DOI: 10.1002/cmdc.200700093)
  121. M. Oba, S. Fukushima, N. Kanayama, K. Aoyagi, N. Nishiyama, H. Koyama, K. Kataoka*, Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directing to cells possessing αvβ3 and αvβ5 integrins. Bioconjugate Chem. 18 (5) 1415-1423 (2007) (DOI: 10.1021/bc0700133)
  122. H. Cabral, N. Nishiyama, K. Kataoka*, Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity. J. Control. Release 121 (3) 146-155 (2007) (DOI: 10.1016/ j.jconrel. 2007.05.024)
  123. M. Han, Y. Bae, N. Nishiyama, K. Miyata, M. Oba, K. Kataoka*, Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J. Control. Release 121 (1-2) 38-48 (2007) (DOI: 10.1016/j.jconrel.2007.05.012)
  124. Y. Bae, N. Nishiyama, K. Kataoka*, In Vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments. Bioconjugate Chem. 18 (4) 1131-1139 (2007) (DOI: 10.1021/bc060401p)
  125. W.-D. Jang*, N. Nishiyama, K. Kataoka, Preparation of naphthalocyanine dendrimer loaded polyion complex micelle for photodynamic therapy. Key Eng. Mater. 342-343 (Advanced Biomaterials VII) 465-468 (2007) (DOI: 10.4028/www.scientific.net/KEM.342-343.465)
  126. W. -D. Jang*, N. Nishiyama, K. Kataoka, Suparmolecular assembly of photofunctional dendrimers for biomedical nano-devices. Supramolecular Chem. 19 (4-5) 309-314 (2007)
  127. D. Akagi, M. Oba, H. Koyama, N. Nishiyama, S. Fukushima, T. Miyata, H. Nagawa, K. Kataoka*, Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation. Gene Ther. 14 (13) 1029-1038 (2007) (DOI: 10.1038/dj.gt.3302945)
  128. M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka*, K. Miyazono*, Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-signaling. Proc. Natl. Acad. Sci. U.S.A. 104 (9) 3460-3465 (2007) (DOI: 10.1073/pnas.0611660104)
  129. Arnida, N. Nishiyama, N. Kanayama, W.-D. Jang, Y. Yamasaki, K. Kataoka*, PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection. J. Control. Release 115 (2) 208-215 (2006) (DOI: 10.1016/j.jconrel.2006.07.014)
  130. N. Nishiyama, Arnida, W.-D. Jang, K. Date, K. Miyata, K. Kataoka*, Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target. 14 (6) 413-424 (2006) (DOI: 10.1080/10611860600834508)
  131. W.-D. Jang, Y. Nakagishi, N. Nishiyama, S. Kawauchi, Y. Morimoto, M. Kikuchi, K. Kataoka*, Polyion complex micelle for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength with enhanced cellular uptake. J. Control. Release 113 (1) 73-79 (2006) (DOI: 10.1016/j.jconrel.2006.03.009)
  132. N. Kanayama, S. Fukushima, N. Nishiyama*, K. Itaka, W.-D. Jang, K. Miyata, Y. Yamasaki, U. Chung, K. Kataoka*, PEG-based biocompatible block catiomer with high-buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. ChemMedChem1 (4) 439-444 (2006) (DOI: 10.1002/cmdc.200600008) [Selected as Cover Picture]
  133. R. Ideta, F. Tasaka, W.-D. Jang, N. Nishiyama, G.-D. Zhang, A. Harada, Y. Yanagi, Y. Tamaki, T. Aida, K. Kataoka*, Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Letters 5 (12) 2426-2431 (2005) (DOI: 10.1021/nl051679d)
  134. K. Miyata, Y. Kakizawa, N. Nishiyama, Y. Yamasaki, T. Watanabe, M. Kohara, K. Kataoka*, Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J. Control. Release 109 (1-3) 15-23 (2005) (DOI: 10.1016/j.jconrel.2005.09.043)
  135. N. Nishiyama, A. Iriyama, W.-D. Jang, K. Miyata, K. Itaka, Y. Inoue, H. Takahashi, Y. Yanagi, Y. Tamaki, H. Koyama, K. Kataoka*, Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nature Mater. 4 (12) 934-941 (2005) (DOI: 10.1038/nmat1524) [Highlighted in Nature 438(7068): 534-535 (2005); Nature Clin. Pract. Neurol. 2(3): 120 (2006); Gene Ther., 13(19): 1371-1372 (2006); Nature Mater. 6(4): 251-253 (2007) ]
  136. H. Uchino, Y. Matsumura*, T. Negishi, F. Koizumi, T. Hayashi, T. Honda, N. Nishiyama, K. Kataoka, S. Naito, T. Kakizoe, Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cispatin in rats. Br. J. Cancer 93 (6) 678-687 (2005) (DOI: 10.1038/sj.bjc.6602772)
  137. Y. Bae, W.-D. Jang, N. Nishiyama, S. Fukushima, K. Kataoka*, Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol. BioSyst. 1 (3) 242-250 (2005) (DOI: 10.1039/b500266d)
  138. Y. Fujihara, H. Koyama*, N. Nishiyama, T. Eguchi, T. Takato, Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap. Br. J. Plast. Surg.58 (4) 511-517 (2005)(DOI: 10.1016/j.bjps.2004.12.028)
  139. S. Fukushima, K. Miyata, N. Nishiyama*, N. Kanayama, Y. Yamasaki, K. Kataoka*, PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J. Am. Chem. Soc. 127 (9) 2810-2811 (2005) (DOI: 10.1021/ja0440506)
  140. M. Oishi, Y. Nagasaki, K. Itaka, N. Nishiyama, K. Kataoka*, Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J. Am. Chem. Soc. 127 (6) 1624-1625 (2005) (DOI: 10.1021/ja044941d)
  141. Y. Bae, N. Nishiyama, S. Fukushima, H. Koyama, Y. Matsumura, K. Kataoka*, Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjugate Chem. 16 (1) 122-130 (2005) (DOI: 10.1021/bc0498166)
  142. W.-D. Jang, N. Nishiyama, G.-D. Zhang, A. Harada, S. Kawauchi, Y. Morimoto, M. Kikuchi, H. Koyama, T. Aida, K. Kataoka*, Suparmolecular nanocarrier of anionic dendrimer porphyrins with PEGylated cationic block copolymer to enhance intracellular photodynamic efficacy. Angew. Chem., Int’l. Ed. 44 (3) 419-423 (2005) (DOI: 10.1002/anie.200461603)
  143. H. Cabral, N. Nishiyama, S. Okazaki, H. Koyama, K. Kataoka*, Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum (II) loaded polymeric micelles. J. Control. Release 101 (1-3) 223-232 (2005) (DOI: 10.1016/j.jconrel.2004.08.022)
  144. A. Hosaka, H. Koyama*, T. Kushibiki, Y. Tabata, N. Nishiyama, T. Miyata, H. Shigematsu, T. Takato, H. Nogawa, Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels. Circulation 110 (21) 3322-3328 (2004) (DOI: 10.1161/​01.CIR.0000147779.17602.18)
  145. D. Wakebayashi, N. Nishiyama, K. Itaka, K. Miyata, Y. Yamasaki, A. Harada, H. Koyama, Y. Nagasaki, K. Kataoka*, Polyion complex micelles of pDNA and acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles of micelles relevant to gene transfection efficacy. Biomacromolecules 5 (6) 2128-2136 (2004) (DOI: 10.1021/bm040009j)
  146. K. Itaka, N. Kanayama, N. Nishiyama, W.-D. Jang, Y. Yamasaki, K. Nakamura, H. Kawaguchi, K. Kataoka*, Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. J. Am. Chem. Soc. 126 (42) 13612-13613 (2004) (DOI: 10.1021/ja047174r)
  147. D. Wakebayashi, N. Nishiyama, Y. Yamasaki, K. Itaka, N. Kanayama, A. Harada, Y. Nagasaki, K. Kataoka*, Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. J. Control. Release95 (3) 653-664 (2004) (DOI: 10.1016/j.jconrel.2004.01.003)
  148. K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, H. Koyama, K. Kataoka*, Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126 (8) 2355-2361 (2004) (DOI: 10.1021/ja0379666)
  149. N. Nishiyama, S. Okazaki, H. Cabral, M. Miyamoto, Y. Kato, Y. Sugiyama, K. Nishio, Y. Matsumura, K. Kataoka*, Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res.63 (24) 8977-8983 (2003)
  150. N. Nishiyama, A. Nori, A. Malugin, Y. Kasuya, P. Kopecková, J. Kopecek*, Free and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. Cancer Res.63 (22) 7876-7882 (2003)
  151. G.-D. Zhang, A. Harada, N. Nishiyama, D.-L. Jiang, H. Koyama, T. Aida, K. Kataoka*, Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer. J. Control. Release93 (2) 141-150 (2003) (DOI: 10.1016/j.jconrel.2003.05.002)
  152. N. Nishiyama, F. Koizumi, S. Okazaki, Y. Matsumura, K. Nishio, K. Kataoka*, Differential gene expression profile between PC-14 cells treated with free cisplatin- and cisplatin-incorporated polymeric micelles. Bioconjugate Chem. 14 (2) 449-457 (2003) (DOI: 10.1021/bc025555t)
  153. G.-D. Zhang, N. Nishiyama, A. Harada, D.-L. Jiang, T. Aida, K. Kataoka*, pH-sensitive assembly of light-Harvesting dendrimer zinc porphyrin bearing peripheral groups of primary amine with poly(ethylene glycol)-b-poly(aspartic acid) in aqueous solution. Macromolecules36 (4) 1304-1309 (2003) (DOI: 10.1021/ma025735y)
  154. N. Nishiyama, H. R. Stapert, T. Nagano, D. Takasu, D.-L. Jiang, T. Aida, K. Kataoka*, Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjugate Chem.14 (1) 58-66 (2003) (DOI: 10.1021/bc025597h)
  155. Y. Mizumura, Y. Matsumura*, T. Hamaguchi, N. Nishiyama, K. Kataoka, T. Kawaguchi, M. Kawaguchi, T. Kakizoe, Cisplatin-incorporated polymeric micelles reducing nephrotoxicity, while maintaining antitumor activity. Jpn J. Cancer Res.92 (3) 328-336 (2001) (DOI: 10.1111/j.1349-7006.2001.tb01099.x)
  156. H. R. Stapert, N. Nishiyama, D.-L. Jiang, T. Aida, K. Kataoka*, Polyion complex micelles encapsulating light-harvesting ionic dendrimer zinc porphyrins. Langmuir 16 (21) 8182-8188 (2000) (DOI: 10.1021/la000423e)
  157. N. Nishiyama, K. Kataoka*, Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the core. J. Control. Release74 (1-3) 83-94 (2001) (DOI: 10.1016/S0168-3659(01)00314-5)
  158. N. Nishiyama, Y. Kato, Y. Sugiyama, K. Kataoka*, Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system. Pharm. Res.18 (7) 1035-1041 (2001) (DOI: 10.1023/A:1010908916184)
  159. N. Nishiyama, M. Yokoyama, T. Aoyagi, T. Okano, Y. Sakurai, K. Kataoka*, Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(α,β-aspartic acid) block copolymer in an aqueous medium. Langmuir 15 (2) 377-383 (1999) (DOI: 10.1021/la980572l)

Review

  1. T. Nomoto, N. Nishiyama*, Design of drug delivery systems for physical energy-induced chemical surgery. Biomaterials in press (2018) (DOI: 10.1016/j.biomaterials.2018.03.038)
  2. H. Takemoto, N. Nishiyama*, Functional polymer-based siRNA delivery carrier that recognizes site- specific biosignals. J. Control. Release 267 90-99 (2017) (DOI: doi: 10.1016/j.jconrel.2017.09.005)
  3. P. Mi, F. Wang, N. Nishiyama, H. Cabral*, Molecular cancer imaging with polymeric nanoassemblies: from tumor detection to theranostics. Macromol. Biosci. 17 (1) (2017) (DOI: 10.1002/mabi.201600305)
  4. N. Nishiyama*, Y. Matsumura, K. Kataoka, Development of polymeric micelles for targeting intractable cancers. Cancer Sci. 107 (7) 867-874 (2016) (DOI: 10.1111/cas.12960)
  5. K. S. Kato*, N. Nishiyama, M. Kozaki, T. Nakanishi, Y. Matsuda, M. Hirano, H. Hanada, S. Hisada, H. Onodera, H. Harashima, Y. Matsumura, K. Kataoka, Y. Goda, H. Okuda, T. Kawanishi, General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation. J. Control. Release 210 76-83 (2015) (DOI: 10.1016/j.jconrel.2015.05.259)
  6. K. Miyata, N. Nishiyama, K. Kataoka*, Rational design of smart supramolecular assemblies for gene delivery: Chemical challenges in the creation of artificial viruses. Chem. Soc. Rev. 41 (7) 2562-2574 (2012) [Selected as Cover Picture]
  7. H. Cabral, N. Nishiyama, K. Kataoka*, Supramolecular nanodevices: From design validation to theranostic nanomedicine. Acc. Chem. Res. 44 (10) 999-1008 (2011)
  8. N. Nishiyama, Y. Morimoto, W.-D. Jang, K. Kataoka*, Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy. Adv. Drug Deliv. Rev. 61 (4) 327-338 (2009) [Selected as Cover Picture]
  9. N. Nishiyama, Nanomedicine: Nanocarriers shape up for long life. Nature Nanotechnol. 2(4): 203-204 (2007)
  10. N. Nishiyama, W.-D. Jang, K. Kataoka*, Supramolecular nanocarriers integrated with dendrimers encapsulating photosensitizers for effective photodynamic therapy and photochemical gene delivery. New J. Chem. 31 (7) 1074-1082 (2007)
  11. N. Nishiyama, K. Kataoka*, Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol. Ther.112 (3) 630-648 (2006)
  12. N. Nishiyama, K. Kataoka*, Nano-structured devices based on block copolymer assemblies for drug delivery: designing structures for enhanced drug function. Adv. Polym. Sci. 193: 67-101 (2006)
  13. N. Nishiyama, Y. Bae, K. Miyata, S. Fukushima, K. Kataoka*, Smart polymeric micelles for gene and drug delivery. Drug Discov. Today: Technologies 2 (1) 21-26 (2005)
  • Tokyo Institute of Technology
  • Department of Environmental Chemistry and Engineering
  • Chemical Resources Laboratory